Ontology highlight
ABSTRACT:
SUBMITTER: Watson JA
PROVIDER: S-EPMC3829029 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Watson Jenny A JA McKenna Declan J DJ Maxwell Perry P Diamond James J Arthur Ken K McKelvey-Martin Valerie J VJ Hamilton Peter W PW
Journal of cellular and molecular medicine 20090706 6B
Histone acetylation is a fundamental mechanism in the regulation of local chromatin conformation and gene expression. Research has focused on the impact of altered epigenetic environments on the expression of specific genes and their pathways. However, changes in histone acetylation also have a global impact on the cell. In this study we used digital texture analysis to assess global chromatin patterns following treatment with trichostatin A (TSA) and have observed significant alterations in the ...[more]