Increased leptin and A-FABP levels in relapsing and progressive forms of MS.

ABSTRACT: Leptin and adipocyte-fatty acid binding protein (A-FABP) are produced by white adipose tissue and may play a role in chronic inflammation in Multiple Sclerosis (MS). To assess leptin and A-FABP in relapsing and progressive forms of MS.Adipokine levels were measured in untreated adult relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS) and Healthy control (HC). Pediatric-onset MS (POMS) and pediatric healthy controls (PHC) were also assessed. Leptin and A-FABP levels were measured in serum by ELISA. Groups were compared using linear mixed-effects model.Excluding two patients with Body Mass Index (BMI)?>?50, a significant difference in leptin level was found between RRMS and HC controlling for age (p?=?0.007), SPMS and HC controlling for age alone (p?=?0.002), or age and BMI (p?=?0.007). A-FABP levels were higher in SPMS than HC (p?=?0.007), controlling for age and BMI. Differences in A-FABP levels between POMS and PHC was observed after controlling for age (p?=?0.019), but not when BMI was added to the model (p?=?0.081).Leptin and A-FABP levels are highest in SPMS compared to HC, suggesting a role in pathogenesis of this disease subtype. A-FABP levels are increased in POMS patients and may play a role in the early stages of disease.

SUBMITTER: Messina S 

PROVIDER: S-EPMC3829106 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature