Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC3829205 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Wang Huating H Garzon Ramiro R Sun Hao H Ladner Katherine J KJ Singh Ravi R Dahlman Jason J Cheng Alfred A Hall Brett M BM Qualman Stephen J SJ Chandler Dawn S DS Croce Carlo M CM Guttridge Denis C DC
Cancer cell 20081101 5
Studies support the importance of microRNAs in physiological and pathological processes. Here we describe the regulation and function of miR-29 in myogenesis and rhabdomyosarcoma (RMS). Results demonstrate that in myoblasts, miR-29 is repressed by NF-kappaB acting through YY1 and the Polycomb group. During myogenesis, NF-kappaB and YY1 downregulation causes derepression of miR-29, which in turn accelerates differentiation by targeting its repressor YY1. However, in RMS cells and primary tumors t ...[more]