Ontology highlight
ABSTRACT:
SUBMITTER: Sirrieh RE
PROVIDER: S-EPMC3829342 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20130621 31
N-Methyl-D-aspartate (NMDA) receptors mediate excitatory neurotransmission in the mammalian central nervous system. An important feature of these receptors is their capacity for allosteric regulation by small molecules, such as zinc, which bind to their amino-terminal domain (ATD). Zinc inhibition through high affinity binding to the ATD has been examined through functional studies; however, there is no direct measurement of associated conformational changes. We used luminescence resonance energ ...[more]