Dataset Information

Invasion patterns in brain metastases of solid cancers.

ABSTRACT:

Background

Brain metastases are generally considered to be well demarcated from the surrounding brain parenchyma, although infiltrative growth patterns have been observed. We systemically investigated infiltration patterns and expression of adhesion molecules in a large and well-defined series of autopsy cases of brain metastases.

Methods

Ninety-seven autopsy specimens from 57 brain metastasis patients (primary tumor: 27 lung cancer, 6 breast cancer, 8 melanoma, 2 colorectal cancer, 1 kidney cancer, and 13 other) were evaluated for patterns of invasion into surrounding brain parenchyma. Expression of integrins ?v; cytoplasmic ?3, ?v?3, ?v?5, ?v?6, and ?v?8; and of E and N cadherin were evaluated using immunohistochemistry.

Results

Three main invasion patterns were seen: well-demarcated growth (29/57, 51%), vascular co-option (10/57, 18%), and diffuse infiltration (18/57, 32%). There was no statistically significant association of invasion pattern with primary tumor type, although vascular co-option was most common in melanoma brain metastases (4/10). Invasion patterns of different brain metastases of the same patient were highly concordant (P < .001, chi-square test). Distance of infiltration from the main tumor mass ranged from 12.5 µm to 450 µm (median 56.2 µm) and was not significantly different between the vascular co-option and the diffuse infiltration groups. Levels of ?v?6 were significantly higher in the well-demarcated group than in the vascular co-option and the diffuse infiltration groups (P = .033, Kruskal-Wallis test). Expression of ?v?5 in tumor cells was higher in brain metastasis lesions previously treated with stereotactic radiosurgery (P = .034, chi-square test).

Conclusions

Distinct invasion patterns of brain metastases into the brain parenchyma are not specific for primary tumor types, seem to be influenced by expression of ?v integrin complexes, and may help to guide clinical decision-making.

SUBMITTER: Berghoff AS

PROVIDER: S-EPMC3829586 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Publications

Invasion patterns in brain metastases of solid cancers.

Berghoff Anna S AS Rajky Orsolya O Winkler Frank F Bartsch Rupert R Furtner Julia J Hainfellner Johannes A JA Goodman Simon L SL Weller Michael M Schittenhelm Jens J Preusser Matthias M

Neuro-oncology 20130930 12

<h4>Background</h4>Brain metastases are generally considered to be well demarcated from the surrounding brain parenchyma, although infiltrative growth patterns have been observed. We systemically investigated infiltration patterns and expression of adhesion molecules in a large and well-defined series of autopsy cases of brain metastases.<h4>Methods</h4>Ninety-seven autopsy specimens from 57 brain metastasis patients (primary tumor: 27 lung cancer, 6 breast cancer, 8 melanoma, 2 colorectal cance ...[more]

PMID: 24084410

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Dataset Information

Invasion patterns in brain metastases of solid cancers.

Background

Methods

Results

Conclusions

Publications

Invasion patterns in brain metastases of solid cancers.

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