Ontology highlight
ABSTRACT:
SUBMITTER: Nadres ET
PROVIDER: S-EPMC3829615 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20130919 19
The scope of palladium-catalyzed, auxiliary-assisted direct arylation and alkylation of sp(2) and sp(3) C-H bonds of amine and carboxylic acid derivatives has been investigated. The method employs a palladium acetate catalyst, substrate, aryl, alkyl, benzyl, or allyl halide, and inorganic base in tert-amyl alcohol or water solvent at 100-140 °C. Aryl and alkyl iodides as well as benzyl and allyl bromides are competent reagents in this transformation. The picolinic acid auxiliary is used for amin ...[more]