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Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer.

ABSTRACT: Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and paired normal adjacent lung tissues, and analyzed its clinicopathological/prognostic significance in NSCLC. Receiver operating characteristic (ROC) curve analysis was utilized to determine a cutoff point (>2 VS. ? 2) for Beclin 1 expression in a training set (n = 105). For validation, the ROC-derived cutoff value was subjected to analysis of the association of Beclin 1 with patients' clinical characteristics and outcome in a testing set (n = 111) and the overall patient cohort (n = 216). Our data showed that Beclin 1 was significantly lower in NSCLC tissues compared with the adjacent normal tissues, negatively associating with tumor recurrence rate (65.8% VS 32.3%; p < 0.001). In the testing set and the overall patient cohort, low expression of Beclin 1 showed significantly inferior overall survival (OS) (p < 0.001) and progression-free survival (PFS) (p < 0.001) compared to high expression of Beclin 1. In the testing set and the overall patient cohort, the median duration of OS for patients with high and low expression of Beclin 1 was 108 VS. 24.5 months (p < 0.001) and 108 VS. 28 months (p < 0.001), respectively. Furthermore, low expression of Beclin 1 was also a poor prognostic factor within each stage of NSCLC patients. Multivariate analysis identified that Beclin 1 was an independent prognostic factor for NSCLC. Our findings in the present study provided evidence that Beclin 1 may thus emerge as an independent prognostic biomarker in this tumor entity in the future.

SUBMITTER: Zhou W

PROVIDER: S-EPMC3829868 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer.

Zhou Weihua W Yue Caifeng C Deng Jinyun J Hu Ronghuan R Xu Jie J Feng Long L Lan Qiongyu Q Zhang Wenfeng W Ji Dexiang D Wu Jianbing J Liu Quentin Q Liu Anwen A

PloS one 20131115 11

Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and paired normal adjacent lung tissues, and analyzed its clinicopathological/prognostic significance in NSCLC. Receiver operating characteristic (ROC) curve analysis was utilized to determine a cutoff point (>2 VS. ≤ 2) for Beclin 1 expression in a tr ...[more]

PMID: 24260370

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Dataset Information

Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer.

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Autophagic protein Beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer.

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