Altered expression of polycomb group genes in glioblastoma multiforme.
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ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC3829908 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Altered expression of polycomb group genes in glioblastoma multiforme.
Li Gang G Warden Charles C Zou Zhaoxia Z Neman Josh J Krueger Joseph S JS Jain Alisha A Jandial Rahul R Chen Mike M
PloS one 20131115 11
The Polycomb group (PcG) proteins play a critical role in histone mediated epigenetics which has been implicated in the malignant evolution of glioblastoma multiforme (GBM). By systematically interrogating The Cancer Genome Atlas (TCGA), we discovered widespread aberrant expression of the PcG members in GBM samples compared to normal brain. The most striking differences were upregulation of EZH2, PHF19, CBX8 and PHC2 and downregulation of CBX7, CBX6, EZH1 and RYBP. Interestingly, changes in EZH2 ...[more]
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