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Synthetic studies toward the citrinadin A and B core architecture.

ABSTRACT: The core architecture of the citrinadin alkaloids has been prepared in racemic form by utilizing a strategy that exploits the alkylation of 2-methoxypyridines. An initially planned indolizidine to quinolizidine transformation to build the D/E rings was unsuccessful. Success was ultimately gained by a direct alkylation to establish the citrinadin core architecture.

SUBMITTER: Mundal DA

PROVIDER: S-EPMC3829995 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Synthetic studies toward the citrinadin A and B core architecture.

Mundal Devon A DA Sarpong Richmond R

Organic letters 20130919 19

The core architecture of the citrinadin alkaloids has been prepared in racemic form by utilizing a strategy that exploits the alkylation of 2-methoxypyridines. An initially planned indolizidine to quinolizidine transformation to build the D/E rings was unsuccessful. Success was ultimately gained by a direct alkylation to establish the citrinadin core architecture. ...[more]

PMID: 24050750

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