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Conflict and error processing in an extended cingulo-opercular and cerebellar network in schizophrenia.

ABSTRACT: The loss of cognitive control is a prominent feature of schizophrenia. Relevant for adaptive control, individuals with schizophrenia often show impairments in their ability to monitor their ongoing behavior, and to adjust their responses based on advance information or feedback. By conducting a systematic examination of the behavioral adjustments after error and conflict and of activity within and between brain regions sensitive to the need to increase control (i.e. error commission, conflict presentation) in individuals with schizophrenia (n = 38) compared to healthy controls, we aimed to 1) shed light on the role of diverse brain regions previously associated with adaptive cognitive control, and 2) contribute to our understanding of the nature of the cognitive deficits present in individuals with schizophrenia. Our results show that error- and conflict-related behavioral adjustments are relatively intact during the performance of a change-signal task. Similarly, individuals with schizophrenia demonstrated intact error- and conflict-related effects in the dorsal anterior cingulate cortex, as well as in a number of other key regions including the bilateral anterior prefrontal cortex (PFC), bilateral insula, right inferior parietal lobule during error processing, and bilateral inferior parietal lobule and thalamus, right anterior PFC, left insula, and left lateral and inferior cerebellum during conflict processing. Given that a critical characteristic of our experimental design was the use of tasks that explicitly provide information about errors and conflict, we interpret our results as suggesting that the error- and conflict-detection systems are still somewhat functional in individuals with schizophrenia, but that a compromise in the ability to represent task relevant information that allow for the generation of an error representation may lead to the alterations in error- and conflict-processing documented in the schizophrenia literature.

SUBMITTER: Becerril KE

PROVIDER: S-EPMC3830057 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Conflict and error processing in an extended cingulo-opercular and cerebellar network in schizophrenia.

Becerril Karla E KE Barch Deanna M DM

NeuroImage. Clinical 20131006

The loss of cognitive control is a prominent feature of schizophrenia. Relevant for adaptive control, individuals with schizophrenia often show impairments in their ability to monitor their ongoing behavior, and to adjust their responses based on advance information or feedback. By conducting a systematic examination of the behavioral adjustments after error and conflict and of activity within and between brain regions sensitive to the need to increase control (i.e. error commission, conflict pr ...[more]

PMID: 24273729

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Project description:Current theories of cognitive dysfunction in schizophrenia emphasize an impairment in the ability of individuals suffering from this disorder to monitor their own performance, and adjust their behavior to changing demands. Detecting an error in performance is a critical component of evaluative functions that allow the flexible adjustment of behavior to optimize outcomes. The dorsal anterior cingulate cortex (dACC) has been repeatedly implicated in error-detection and implementation of error-based behavioral adjustments. However, accurate error-detection and subsequent behavioral adjustments are unlikely to rely on a single brain region. Recent research demonstrates that regions in the anterior insula, inferior parietal lobule, anterior prefrontal cortex, thalamus, and cerebellum also show robust error-related activity, and integrate into a functional network. Despite the relevance of examining brain activity related to the processing of error information and supporting behavioral adjustments in terms of a distributed network, the contribution of regions outside the dACC to error processing remains poorly understood. To address this question, we used functional magnetic resonance imaging to examine error-related responses in 37 individuals with schizophrenia and 32 healthy controls in regions identified in the basic science literature as being involved in error processing, and determined whether their activity was related to behavioral adjustments. Our imaging results support previous findings showing that regions outside the dACC are sensitive to error commission, and demonstrated that abnormalities in brain responses to errors among individuals with schizophrenia extend beyond the dACC to almost all of the regions involved in error-related processing in controls. However, error related responses in the dACC were most predictive of behavioral adjustments in both groups. Moreover, the integration of this network of regions differed between groups, with the cerebellar regions and the dACC less connected to the network in individuals with schizophrenia compared to controls. Our findings demonstrate a blunted response to error commission in the dACC that is associated with reduced error-related behavioral adjustments in individuals with schizophrenia. This result supports the hypothesis that a failure to respond appropriately to errors in individuals with schizophrenia is linked to alterations in dACC function leading to a compromise in the implementation of cognitive control. Our findings highlight the importance of examining brain activity related to the processing of error information and supporting error-related behavioral adjustments in terms of a distributed network.

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Dataset Information

Conflict and error processing in an extended cingulo-opercular and cerebellar network in schizophrenia.

Publications

Conflict and error processing in an extended cingulo-opercular and cerebellar network in schizophrenia.

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