Riboswitches in eubacteria sense the second messenger c-di-AMP.
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ABSTRACT:
SUBMITTER: Nelson JW
PROVIDER: S-EPMC3830699 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Riboswitches in eubacteria sense the second messenger c-di-AMP.
Nelson James W JW Sudarsan Narasimhan N Furukawa Kazuhiro K Weinberg Zasha Z Wang Joy X JX Breaker Ronald R RR
Nature chemical biology 20131020 12
Cyclic di-adenosine monophosphate (c-di-AMP) is a recently discovered bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. However, the mechanisms by which c-di-AMP triggers these physiological responses have remained largely unknown. Notably, a candidate riboswitch class called ydaO associates with numerous genes involved in these same processes. Although a representative ydaO motif RNA recently was reported to weakly bind ATP, ...[more]
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