Ontology highlight
ABSTRACT:
SUBMITTER: Bailey RM
PROVIDER: S-EPMC3830748 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Bailey Rachel M RM Covy Jason P JP Melrose Heather L HL Rousseau Linda L Watkinson Ruth R Knight Joshua J Miles Sarah S Farrer Matthew J MJ Dickson Dennis W DW Giasson Benoit I BI Lewis Jada J
Acta neuropathologica 20131011 6
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial Parkinson's disease (PD). The neuropathology of LRRK2-related PD is heterogeneous and can include aberrant tau phosphorylation or neurofibrillary tau pathology. Recently, LRRK2 has been shown to phosphorylate tau in vitro; however, the major epitopes phosphorylated by LRRK2 and the physiological or pathogenic consequences of these modifications in vivo are unknown. Using mass spectrometry, ...[more]