Ontology highlight
ABSTRACT:
SUBMITTER: Cai S
PROVIDER: S-EPMC3830956 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Cai Sumin S Li Qing-Shan QS Borchardt Ronald T RT Kuczera Krzysztof K Schowen Richard L RL
Bioorganic & medicinal chemistry 20070824 23
Ribavirin (1,2,4-triazole-3-carboxamide riboside) is a well-known antiviral drug. Ribavirin has also been reported to inhibit human S-adenosyl-L-homocysteine hydrolase (Hs-SAHH), which catalyzes the conversion of S-adenosyl-L-homocysteine to adenosine and homocysteine. We now report that ribavirin, which is structurally similar to adenosine, produces time-dependent inactivation of Hs-SAHH and Trypanosoma cruzi SAHH (Tc-SAHH). Ribavirin binds to the adenosine-binding site of the two SAHHs and red ...[more]