Ontology highlight
ABSTRACT:
SUBMITTER: Panda S
PROVIDER: S-EPMC3831310 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Panda Saswati S Zhang Jing J Tan Nguan Soon NS Ho Bow B Ding Jeak Ling JL
The EMBO journal 20130903 22
For nearly five decades since its discovery, the role of natural IgG, which pre-exists in neonates and uninfected individuals, has remained unclear due to the general perception that natural antibodies lack affinity for pathogens. Here, we show for the first time that natural IgG recognizes a spectrum of bacteria through lectins like ficolin and mannose binding lectin (MBL). Infection-inflammation condition markedly increased the affinity of natural IgG for bacteria associated with ficolins. Aft ...[more]