Ontology highlight
ABSTRACT:
SUBMITTER: Cui TX
PROVIDER: S-EPMC3831370 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Cui Tracy X TX Kryczek Ilona I Zhao Lili L Zhao Ende E Kuick Rork R Roh Michael H MH Vatan Linda L Szeliga Wojciech W Mao Yujun Y Thomas Dafydd G DG Kotarski Jan J Tarkowski Rafał R Wicha Max M Cho Kathleen K Giordano Thomas T Liu Rebecca R Zou Weiping W
Immunity 20130905 3
Myeloid-derived suppressor cells (MDSCs) and cancer stem cells (CSCs) are important cellular components in the cancer microenvironment and may affect cancer phenotype and patient outcome. The nature of MDSCs and their interaction with CSCs in ovarian carcinoma are unclear. We examined the interaction between MDSCs and CSCs in patients with ovarian carcinoma and showed that MDSCs inhibited T cell activation and enhanced CSC gene expression, sphere formation, and cancer metastasis. MDSCs triggered ...[more]