Ontology highlight
ABSTRACT:
SUBMITTER: Theendakara V
PROVIDER: S-EPMC3831497 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Theendakara Veena V Patent Alexander A Peters Libeu Clare A CA Philpot Brittany B Flores Sonia S Descamps Olivier O Poksay Karen S KS Zhang Qiang Q Cailing Gabriellee G Hart Matthew M John Varghese V Rao Rammohan V RV Bredesen Dale E DE
Proceedings of the National Academy of Sciences of the United States of America 20131021 45
The canonical pathogenesis of Alzheimer's disease links the expression of apolipoprotein E ε4 allele (ApoE) to amyloid precursor protein (APP) processing and Aβ peptide accumulation by a set of mechanisms that is incompletely defined. The development of a simple system that focuses not on a single variable but on multiple factors and pathways would be valuable both for dissecting the underlying mechanisms and for identifying candidate therapeutics. Here we show that, although both ApoE3 and ApoE ...[more]