Ontology highlight
ABSTRACT:
SUBMITTER: Parker JL
PROVIDER: S-EPMC3831681 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Parker Joanne L JL Newstead Simon S
Protein science : a publication of the Protein Society 20130917 11
In this report we highlight the latest trends in phasing methods used to solve alpha helical membrane protein structures and analyze the use of heavy atom metals for the purpose of experimental phasing. Our results reveal that molecular replacement is emerging as the most successful method for phasing alpha helical membrane proteins, with the notable exception of the transporter family, where experimentally derived phase information still remains the most effective method. To facilitate selectio ...[more]