Ontology highlight
ABSTRACT:
SUBMITTER: Lam TI
PROVIDER: S-EPMC3832003 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Lam Tina I TI Brennan-Minnella Angela M AM Won Seok Joon SJ Shen Yiguo Y Hefner Colleen C Shi Yejie Y Sun Dandan D Swanson Raymond A RA
Proceedings of the National Academy of Sciences of the United States of America 20131025 46
Sustained activation of N-methyl-d-aspartate (NMDA) -type glutamate receptors leads to excitotoxic neuronal death in stroke, brain trauma, and neurodegenerative disorders. Superoxide production by NADPH oxidase is a requisite event in the process leading from NMDA receptor activation to excitotoxic death. NADPH oxidase generates intracellular H(+) along with extracellular superoxide, and the intracellular H(+) must be released or neutralized to permit continued NADPH oxidase function. In culture ...[more]