Ontology highlight
ABSTRACT:
SUBMITTER: Alnajar A
PROVIDER: S-EPMC3832604 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Alnajar Abdulaleem A Nordhoff Carolin C Schied Tanja T Chiquet-Ehrismann Ruth R Loser Karin K Vogl Thomas T Ludwig Stephan S Wixler Viktor V
PloS one 20131118 11
Fibrogenesis is usually initiated when regenerative processes have failed and/or chronic inflammation occurs. It is characterised by the activation of tissue fibroblasts and dysregulated synthesis of extracellular matrix proteins. FHL2 (four-and-a-half LIM domain protein 2) is a scaffolding protein that interacts with numerous cellular proteins, regulating signalling cascades and gene transcription. It is involved in tissue remodelling and tumour progression. Recent data suggest that FHL2 might ...[more]