Ontology highlight
ABSTRACT:
SUBMITTER: Nuvolone M
PROVIDER: S-EPMC3832919 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Nuvolone Mario M Kana Veronika V Hutter Gregor G Sakata Daiji D Mortin-Toth Steven M SM Russo Giancarlo G Danska Jayne S JS Aguzzi Adriano A
The Journal of experimental medicine 20131021 12
Prnp(-/-) mice lack the prion protein PrP(C) and are resistant to prion infections, but variable phenotypes have been reported in Prnp(-/-) mice and the physiological function of PrP(C) remains poorly understood. Here we examined a cell-autonomous phenotype, inhibition of macrophage phagocytosis of apoptotic cells, previously reported in Prnp(-/-) mice. Using formal genetic, genomic, and immunological analyses, we found that the regulation of phagocytosis previously ascribed to PrP(C) is instead ...[more]