Ontology highlight
ABSTRACT:
SUBMITTER: He JS
PROVIDER: S-EPMC3832920 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
He Jin-Shu JS Meyer-Hermann Michael M Xiangying Deng D Zuan Lim Yok LY Jones Leigh Ann LA Ramakrishna Lakshmi L de Vries Victor C VC Dolpady Jayashree J Aina Hoi H Joseph Sabrina S Narayanan Sriram S Subramaniam Sharrada S Puthia Manoj M Wong Glenn G Xiong Huizhong H Poidinger Michael M Urban Joseph F JF Lafaille Juan J JJ Curotto de Lafaille Maria A MA
The Journal of experimental medicine 20131111 12
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaire ...[more]