Ontology highlight
ABSTRACT:
SUBMITTER: Cekic C
PROVIDER: S-EPMC3832923 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Cekic Caglar C Sag Duygu D Day Yuan-Ji YJ Linden Joel J
The Journal of experimental medicine 20131021 12
Adenosine produced as a byproduct of metabolic activity is present in all tissues and produces dose-dependent suppression of TCR signaling. Naive T cell maintenance depends on inhibition of TCR signals by environmental sensors, which are yet to be fully defined. We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show that either global A2AR deletion or cre-mediated T cell deletion elicits a decline in the number of naive but not memory T cells. A2AR signaling maintai ...[more]