Ontology highlight
ABSTRACT:
SUBMITTER: King IL
PROVIDER: S-EPMC3833037 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
King Irah L IL Fortier Anne A Tighe Michael M Dibble John J Watts Gerald F M GF Veerapen Natacha N Haberman Ann M AM Besra Gurdyal S GS Mohrs Markus M Brenner Michael B MB Leadbetter Elizabeth A EA
Nature immunology 20111127 1
Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that ...[more]