Multiparametric image analysis of lung-branching morphogenesis.
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ABSTRACT:
SUBMITTER: Schnatwinkel C
PROVIDER: S-EPMC3833092 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Multiparametric image analysis of lung-branching morphogenesis.
Schnatwinkel Carsten C Niswander Lee L
Developmental dynamics : an official publication of the American Association of Anatomists 20130423 6
<h4>Background</h4>Lung-branching morphogenesis is a fundamental developmental process, yet the cellular dynamics that occur during lung development and the molecular mechanisms underlying recent postulated branching modes are poorly understood.<h4>Results</h4>Here, we implemented a time-lapse video microscopy method to study the cellular behavior and molecular mechanisms of planar bifurcation and domain branching in lung explant- and organotypic cultures. Our analysis revealed morphologically d ...[more]
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