Ontology highlight
ABSTRACT:
SUBMITTER: Cukier CD
PROVIDER: S-EPMC3833349 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Cukier Cyprian D CD Hope Anthony G AG Elamin Ayssar A AA Moynie Lucile L Schnell Robert R Schach Susanne S Kneuper Holger H Singh Mahavir M Naismith James H JH Lindqvist Ylva Y Gray David W DW Schneider Gunter G
ACS chemical biology 20130923 11
3-Oxo-acyl-acyl carrier protein (ACP) reductase (FabG) plays a key role in the bacterial fatty acid synthesis II system in pathogenic microorganisms, which has been recognized as a potential drug target. FabG catalyzes reduction of a 3-oxo-acyl-ACP intermediate during the elongation cycle of fatty acid biosynthesis. Here, we report gene deletion experiments that support the essentiality of this gene in P. aeruginosa and the identification of a number of small molecule FabG inhibitors with IC50 v ...[more]