Ontology highlight
ABSTRACT:
SUBMITTER: Heidersbach A
PROVIDER: S-EPMC3833424 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Heidersbach Amy A Saxby Chris C Carver-Moore Karen K Huang Yu Y Ang Yen-Sin YS de Jong Pieter J PJ Ivey Kathryn N KN Srivastava Deepak D
eLife 20131119
microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus, miR-1-2, causes incompletely penetrant lethality and subtle cardiac defects. Here, we report that deletion of miR-1-1 resulted in a phenotype similar to that of the miR-1-2 mutant. Compound miR-1 knockout mice died uniformly before weaning due to severe cardiac dysfunction. miR-1-null cardiomyocytes had abnormal sarcomere ...[more]