Ontology highlight
ABSTRACT:
SUBMITTER: Hussain SK
PROVIDER: S-EPMC3833442 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Hussain Shehnaz K SK Madeleine Margaret M MM Johnson Lisa G LG Du Qin Q Galloway Denise A DA Daling Janet R JR Malkki Mari M Petersdorf Effie W EW Schwartz Stephen M SM
International journal of cancer 20130212 1
Given the important role of cell mediated immunity in viral clearance and control of premalignant lesions, we hypothesize that variation in the IL-12/IL-10 cytokine and cytokine receptor genes may influence cervical and vulvar cancer risk. We evaluated 76 tagSNPs from seven candidate genes (IL-10, IL-12A, IL-12B, IL-10RA, IL-10RB, IL-12RB1, and IL12RB2) in case-parent sets (n=43 cervical squamous cell carcinoma (SCC), n=96 cervical adenocarcinoma, n=53 vulvar SCC), additional cases (n=356 cervic ...[more]