Ontology highlight
ABSTRACT:
SUBMITTER: Hoshino K
PROVIDER: S-EPMC3833718 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Hoshino Koyu K Quintás-Cardama Alfonso A Radich Jerald J Dai Hongyui H Yang Hui H Garcia-Manero Guillermo G
Leukemia research 20090505 10
JUNB inactivation in transgenic mice results in a myeloproliferative disorder that closely resembles human chronic myelogenous leukemia (CML). It has been reported that downregulation of JUNB expression is a universal phenomenon in patients with CML due aberrant DNA methylation of its promoter. Based on this, we studied methylation and gene expression levels of JUNB in CML. We analyzed the methylation status of the JUNB gene in 6 cell lines and in 102 patients with CML using several bisulfite PC ...[more]