Ontology highlight
ABSTRACT:
SUBMITTER: Duah E
PROVIDER: S-EPMC3834363 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Duah Ernest E Adapala Ravi K RK Al-Azzam Nosayba N Kondeti Vinay V Gombedza Farai F Thodeti Charles K CK Paruchuri Sailaja S
Scientific reports 20131120
Cysteinyl leukotrienes (cys-LTs), LTC₄, LTD₄, LTE₄ are potent inflammatory lipid mediators that act through two distinct G-protein-coupled receptors, CysLT₁R and CysLT₂R. Although cys-LTs are shown to induce vascular leakage and atherosclerosis, the molecular mechanism by which cys-LTs modulate endothelial function is not known. Here, we show that cys-LTs (LTC₄ and LTD₄) induce robust calcium influx in human umbilical vein endothelial cells (HUVECs) through CysLT₂R, but not CysLT₁R. Further, cys ...[more]