Ontology highlight
ABSTRACT:
SUBMITTER: McAlary L
PROVIDER: S-EPMC3834562 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20131120
Dissociation of superoxide dismutase 1 dimers is enhanced by glutathionylation, although the dissociation constants reported to date are imprecise. We have quantified the discreet dissociation constants for wild-type superoxide dismutase 1 and six naturally occurring sequence variants, in their unmodified and glutathionylated forms, at the ratios expressed. Unmodified superoxide dismutase 1 variants that shared similar dissociation constants with SOD1(WT) had disproportionately increased dissoci ...[more]