Ontology highlight
ABSTRACT:
SUBMITTER: Mills LJ
PROVIDER: S-EPMC3834790 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Mills Lauren J LJ Pearson William R WR
Bioinformatics (Oxford, England) 20130831 23
<h4>Motivation</h4>Sequence similarity searches performed with BLAST, SSEARCH and FASTA achieve high sensitivity by using scoring matrices (e.g. BLOSUM62) that target low identity (<33%) alignments. Although such scoring matrices can effectively identify distant homologs, they can also produce local alignments that extend beyond the homologous regions.<h4>Results</h4>We measured local alignment start/stop boundary accuracy using a set of queries where the correct alignment boundaries were known, ...[more]