Ontology highlight
ABSTRACT:
SUBMITTER: Kitson RR
PROVIDER: S-EPMC3835074 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Kitson Russell R A RR Moody Christopher J CJ
Chemical communications (Cambridge, England) 20131001 76
19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids. ...[more]