Targeting RSV with vaccines and small molecule drugs.
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ABSTRACT:
SUBMITTER: Costello HM
PROVIDER: S-EPMC3835183 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Targeting RSV with vaccines and small molecule drugs.
Costello Heather M HM Ray William C WC Chaiwatpongsakorn Supranee S Peeples Mark E ME
Infectious disorders drug targets 20120401 2
Respiratory syncytial virus (RSV) is the most significant cause of pediatric respiratory infections. Palivizumab (Synagis®), a humanized monoclonal antibody, has been used successfully for a number of years to prevent severe RSV disease in at-risk infants. However, despite intense efforts, there is no approved vaccine or small molecule drug for RSV. As an enveloped virus, RSV must fuse its envelope with the host cell membrane, which is accomplished through the actions of the fusion (F) glycoprot ...[more]
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