Ontology highlight
ABSTRACT:
SUBMITTER: Yin F
PROVIDER: S-EPMC3835333 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Yin Feng F Yu Jianzhong J Zheng Yonggang Y Chen Qian Q Zhang Nailing N Pan Duojia D
Cell 20130905 6
Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying Neurofibromatosis type II, its precise molecular mechanism remains poorly understood. Recent studies in Drosophila revealed a potential link between Merlin and the Hippo pathway by placing Merlin genetically upstream of the kinase Hpo/Mst. In contrast to the commonly depicted linear model of Merlin functioning through Hpo/Mst, here we show that in both Drosophila and mammals, Merlin promotes downstream Hippo sign ...[more]