Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.
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ABSTRACT:
SUBMITTER: Civitarese AE
PROVIDER: S-EPMC3835349 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.
Civitarese Anthony E AE MacLean Paul S PS Carling Stacy S Kerr-Bayles Lyndal L McMillan Ryan P RP Pierce Anson A Becker Thomas C TC Moro Cedric C Finlayson Jean J Lefort Natalie N Newgard Christopher B CB Mandarino Lawrence L Cefalu William W Walder Ken K Collier Greg R GR Hulver Matthew W MW Smith Steven R SR Ravussin Eric E
Cell metabolism 20100501 5
Type 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and impaired mitochondrial energetics. In lower organisms, remodeling by the protease pcp1 (PARL ortholog) maintains the function and lifecycle of mitochondria. We examined whether variation in PARL protein content is associated with mitochondrial abnormalities and insulin resistance. PARL mRNA and mitochondrial mass were both reduced in elderly subjects and in subjects with T2DM. Muscle knockdown of PARL in mice r ...[more]
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