Category-specific integration of homeostatic signals in caudal but not rostral human insula.
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ABSTRACT:
SUBMITTER: Simmons WK
PROVIDER: S-EPMC3835665 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
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Category-specific integration of homeostatic signals in caudal but not rostral human insula.
Simmons W Kyle WK Rapuano Kristina M KM Kallman Seth J SJ Ingeholm John E JE Miller Bernard B Gotts Stephen J SJ Avery Jason A JA Hall Kevin D KD Martin Alex A
Nature neuroscience 20130929 11
Prevailing theories hold that the insula is functionally organized along its caudal-to-rostral axis, with posterior regions coding lower-level sensory information and anterior regions coding higher-level stimulus significance relative to the body's homeostatic needs. Contrary to predictions of this model, the response of the taste-sensitive region of the caudal, but not rostral, insula to food images was directly related to the body's homeostatic state as indexed by levels of peripheral glucose. ...[more]
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