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ABSTRACT: Objectives
A cross-sectional epidemiological study explored genetic susceptibility to oral precancer and cancer in Puerto Rico (PR).Materials and methods
Three hundred three individuals with a benign oral condition, oral precancer (oral epithelial hyperplasia/hyperkeratosis, oral epithelial dysplasia), or oral squamous cell carcinoma (SCCA) were identified via PR pathology laboratories. A standardized, structured questionnaire obtained information on epidemiological variables; buccal cells were collected for genetic analysis. Genotyping was performed using Taqman® assays. Allelic frequencies of single nucleotide polymorphisms (SNPs) were evaluated in cytokine genes and genes influencing tumor metastasis. Risk estimates for a diagnosis of oral precancer or SCCA while having a variant allele were generated using logistic regression. Adjusted models controlled for age, gender, ancestry, education, smoking and alcohol consumption.Results
Relative to persons with a benign oral lesion, individuals with homozygous recessive allelic variants of tumor necrosis factor (TNF-?) -238 A/G SNP had a reduced odds of having an oral precancer (ORadjusted?=?0.15; 95% CI 0.03-0.70). The transforming growth factor beta-1 (TGF?-1 -509 C/T) polymorphism was inversely associated with having an oral SCCA among persons homozygous for the recessive variant (ORcrude?=?0.27; 95% CI 0.09-0.79). The matrix metalloproteinase gene (MMP-1) variant, rs5854, was associated with oral SCCA; participants with even one variant allele were more likely to have oral SCCA (ORadjusted?=?2.62, 95% CI 1.05-6.53) compared to people with ancestral alleles.Conclusion
Our exploratory analyses suggest that genetic alterations in immune system genes and genes with metastatic potential are associated with oral precancer and SCCA risk in PR.
SUBMITTER: Erdei E
PROVIDER: S-EPMC3835869 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Erdei Esther E Luo Li L Sheng Huiping H Maestas Erika E White Kirsten A M KA Mackey Amanda A Dong Yan Y Berwick Marianne M Morse Douglas E DE
PloS one 20131120 11
<h4>Objectives</h4>A cross-sectional epidemiological study explored genetic susceptibility to oral precancer and cancer in Puerto Rico (PR).<h4>Materials and methods</h4>Three hundred three individuals with a benign oral condition, oral precancer (oral epithelial hyperplasia/hyperkeratosis, oral epithelial dysplasia), or oral squamous cell carcinoma (SCCA) were identified via PR pathology laboratories. A standardized, structured questionnaire obtained information on epidemiological variables; bu ...[more]