Ontology highlight
ABSTRACT:
SUBMITTER: Karschner EL
PROVIDER: S-EPMC3836266 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Karschner E L EL Darwin W D WD McMahon R P RP Liu F F Wright S S Goodwin R S RS Huestis M A MA
Clinical pharmacology and therapeutics 20110202 3
Sativex is a cannabis-plant extract delivering nearly 1:1 Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) by oromucosal spray. It has been suggested that CBD attenuates THC-induced tachycardia, anxiety, and euphoria. In this study, pharmacodynamic effects were compared over 10.5 h in nine cannabis smokers randomly assigned to receive placebo, 5 and 15 mg oral synthetic THC, and low (5.4 mg THC, 5.0 mg CBD) and high (16.2 mg THC, 15.0 mg CBD) doses of Sativex. At therapeutic doses, no subst ...[more]