Subjective and physiological effects after controlled Sativex and oral THC administration.
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ABSTRACT:
SUBMITTER: Karschner EL
PROVIDER: S-EPMC3836266 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
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Subjective and physiological effects after controlled Sativex and oral THC administration.
Karschner E L EL Darwin W D WD McMahon R P RP Liu F F Wright S S Goodwin R S RS Huestis M A MA
Clinical pharmacology and therapeutics 20110202 3
Sativex is a cannabis-plant extract delivering nearly 1:1 Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD) by oromucosal spray. It has been suggested that CBD attenuates THC-induced tachycardia, anxiety, and euphoria. In this study, pharmacodynamic effects were compared over 10.5 h in nine cannabis smokers randomly assigned to receive placebo, 5 and 15 mg oral synthetic THC, and low (5.4 mg THC, 5.0 mg CBD) and high (16.2 mg THC, 15.0 mg CBD) doses of Sativex. At therapeutic doses, no subst ...[more]
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