Ontology highlight
ABSTRACT:
SUBMITTER: Agyin JK
PROVIDER: S-EPMC3836429 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Agyin Joseph K JK Santhamma Bindu B Roy Sudipa S SS
Bioorganic & medicinal chemistry letters 20130921 23
Multiple myeloma (MM) is an incurable neoplasm characterized by devastating and progressive bone destruction. Standard chemotherapeutic agents have not been effective at significantly prolonging the survival of MM patients and these agents are typically associated with often severe, dose-limiting side effects. There is great need for methods to target the delivery of novel, effective cytotoxic agents specifically to bone, where myeloma cells reside. We have synthesized and evaluated the effects ...[more]