Ontology highlight
ABSTRACT:
SUBMITTER: Waller AK
PROVIDER: S-EPMC3836464 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20130802 12
Impaired healing is common in wounds infected with the major human pathogen Staphylococcus aureus, although the underlying mechanisms are poorly understood. Here, we show that S. aureus lipoteichoic acid (LTA) inhibits platelet aggregation caused by physiological agonists and S. aureus and reduced platelet thrombus formation in vitro. The presence of D-alanine on LTA is necessary for the full inhibitory effect. Inhibition of aggregation was blocked using a monoclonal anti-platelet activating fac ...[more]