Ontology highlight
ABSTRACT:
SUBMITTER: D'Alessandro R
PROVIDER: S-EPMC3836575 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
D'Alessandro Rosalba R Refolo Maria G MG Lippolis Catia C Messa Caterina C Cavallini Aldo A Rossi Roberta R Resta Leonardo L Di Carlo Antonio A Carr Brian I BI
Cancer chemotherapy and pharmacology 20131001 4
<h4>Purpose</h4>Multikinase growth inhibitors inhibit their target kinases with varying potency. Patients often require lower doses or therapy breaks due to drug toxicities. To evaluate the effects of drug withdrawal on hepatocellular carcinoma cells after incubation with growth-inhibitory concentrations of regorafenib, cell growth, migration and invasion, and signaling were examined.<h4>Methods</h4>Cell proliferation, motility, and invasion were analyzed by MTT, wound healing, and invasion assa ...[more]