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Isolation of saint louis encephalitis virus from a horse with neurological disease in Brazil.


ABSTRACT: St. Louis encephalitis virus (SLEV) is a causative agent of encephalitis in humans in the Western hemisphere. SLEV is a positive-sense RNA virus that belongs to the Flavivirus genus, which includes West Nile encephalitis virus, Japanese encephalitis virus, Dengue virus and other medically important viruses. Recently, we isolated a SLEV strain from the brain of a horse with neurological signs in the countryside of Minas Gerais, Brazil. The SLEV isolation was confirmed by reverse-transcription RT-PCR and sequencing of the E protein gene. Virus identity was also confirmed by indirect immunofluorescence using commercial antibodies against SLEV. To characterize this newly isolated strain in vivo, serial passages in newborn mice were performed and led to hemorrhagic manifestations associated with recruitment of inflammatory cells into the central nervous system of newborns. In summary this is the first isolation of SLEV from a horse with neurological signs in Brazil.

SUBMITTER: Rosa R 

PROVIDER: S-EPMC3836713 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Isolation of saint louis encephalitis virus from a horse with neurological disease in Brazil.

Rosa Roberta R   Costa Erica Azevedo EA   Marques Rafael Elias RE   Oliveira Taismara Simas TS   Furtini Ronaldo R   Bomfim Maria Rosa Quaresma MR   Teixeira Mauro Martins MM   Paixão Tatiane Alves TA   Santos Renato Lima RL  

PLoS neglected tropical diseases 20131121 11


St. Louis encephalitis virus (SLEV) is a causative agent of encephalitis in humans in the Western hemisphere. SLEV is a positive-sense RNA virus that belongs to the Flavivirus genus, which includes West Nile encephalitis virus, Japanese encephalitis virus, Dengue virus and other medically important viruses. Recently, we isolated a SLEV strain from the brain of a horse with neurological signs in the countryside of Minas Gerais, Brazil. The SLEV isolation was confirmed by reverse-transcription RT-  ...[more]

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