Ontology highlight
ABSTRACT:
SUBMITTER: Everitt AR
PROVIDER: S-EPMC3836756 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Everitt Aaron R AR Clare Simon S McDonald Jacqueline U JU Kane Leanne L Harcourt Katherine K Ahras Malika M Lall Amar A Hale Christine C Rodgers Angela A Young Douglas B DB Haque Ashraful A Billker Oliver O Tregoning John S JS Dougan Gordon G Kellam Paul P
PloS one 20131121 11
The interferon-inducible transmembrane (IFITM) family of proteins has been shown to restrict a broad range of viruses in vitro and in vivo by halting progress through the late endosomal pathway. Further, single nucleotide polymorphisms (SNPs) in its sequence have been linked with risk of developing severe influenza virus infections in humans. The number of viruses restricted by this host protein has continued to grow since it was first demonstrated as playing an antiviral role; all of which ente ...[more]