Ontology highlight
ABSTRACT:
SUBMITTER: Dooley KE
PROVIDER: S-EPMC3837382 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20120501 5
Rifapentine (RP T) is an antituberculosis drug that may shorten treatment duration when substituted for rifampin (RI F).The maximal tolerated daily dose of RP T and its potential for cytochrome 3A4 induction and autoinduction at clinically relevant doses are unknown. In this phase I, dose-escalation study among healthy volunteers, daily doses as high asa prespecified maximum of 20 mg/kg/day were well tolerated. Steady-state RP T concentrations increased with dose from 5 to 15 mg/kg, but area und ...[more]