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Nanomechanics of streptavidin hubs for molecular materials.

ABSTRACT: A new strategy is reported for creating protein-based nanomaterials by genetically fusing large polypeptides to monomeric streptavidin and exploiting the propensity of streptavidin monomers(SM) to self-assemble into stable tetramers. We have characterized the mechanical properties of streptavidin-linked structures and measured, for the first time, the mechanical strength of streptavidin tetramers themselves. Using streptavidin tetramers as molecular hubs offers a unique opportunity to create a variety of well-defined, self-assembled protein-based (nano)materials with unusual mechanical properties.

SUBMITTER: Kim M

PROVIDER: S-EPMC3837471 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Nanomechanics of streptavidin hubs for molecular materials.

Kim Minkyu M Wang Chien-Chung CC Benedetti Fabrizio F Rabbi Mahir M Bennett Vann V Marszalek Piotr E PE

Advanced materials (Deerfield Beach, Fla.) 20111121 47

A new strategy is reported for creating protein-based nanomaterials by genetically fusing large polypeptides to monomeric streptavidin and exploiting the propensity of streptavidin monomers(SM) to self-assemble into stable tetramers. We have characterized the mechanical properties of streptavidin-linked structures and measured, for the first time, the mechanical strength of streptavidin tetramers themselves. Using streptavidin tetramers as molecular hubs offers a unique opportunity to create a v ...[more]

PMID: 22102445

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