Ontology highlight
ABSTRACT:
SUBMITTER: Wilson CW
PROVIDER: S-EPMC3837516 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Wilson Christopher W CW Parker Leon H LH Hall Christopher J CJ Smyczek Tanya T Mak Judy J Crow Ailey A Posthuma George G De Mazière Ann A Sagolla Meredith M Chalouni Cecile C Vitorino Philip P Roose-Girma Merone M Warming Søren S Klumperman Judith J Crosier Philip S PS Ye Weilan W
Blood 20130725 22
Establishment and stabilization of endothelial tubes with patent lumens is vital during vertebrate development. Ras-interacting protein 1 (RASIP1) has been described as an essential regulator of de novo lumenogenesis through modulation of endothelial cell (EC) adhesion to the extracellular matrix (ECM). Here, we show that in mouse and zebrafish embryos, Rasip1-deficient vessels transition from an angioblast cord to a hollow tube, permit circulation of primitive erythrocytes, but ultimately colla ...[more]