Ontology highlight
ABSTRACT:
SUBMITTER: Li DD
PROVIDER: S-EPMC3837902 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Li De-Dong DD Xu Yi Y Zhang Da-Zhi DZ Quan Hua H Mylonakis Eleftherios E Hu Dan-Dan DD Li Ming-Bang MB Zhao Lan-Xue LX Zhu Liang-Hua LH Wang Yan Y Jiang Yuan-Ying YY
Antimicrobial agents and chemotherapy 20130923 12
It was found in our previous study that berberine (BBR) and fluconazole (FLC) used concomitantly exhibited a synergism against FLC-resistant Candida albicans in vitro. The aim of the present study was to clarify how BBR and FLC worked synergistically and the underlying mechanism. Antifungal time-kill curves indicated that the synergistic effect of the two drugs was BBR dose dependent rather than FLC dose dependent. In addition, we found that BBR accumulated in C. albicans cells, especially in th ...[more]