Ontology highlight
ABSTRACT:
SUBMITTER: Parsy ML
PROVIDER: S-EPMC3838125 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Journal of virology 20130918 23
Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1-Å resolution in the postfusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat, and consideration of glycan dynamics reveals extensive coverage of the underlying ...[more]