Ontology highlight
ABSTRACT:
SUBMITTER: Poojari C
PROVIDER: S-EPMC3838749 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Poojari Chetan C Xiao Dequan D Batista Victor S VS Strodel Birgit B
Biophysical journal 20131101 10
Several neurodegenerative diseases such as Alzheimer's and Parkinson's diseases as well as nonneuropathic diseases such as type II diabetes and atrial amyloidosis are associated with aggregation of amyloid polypeptides into fibrillar structures, or plaques. In this study, we use molecular dynamics simulations to test the stability and orientation of membrane-embedded aggregates of the human islet amyloid polypeptide (hIAPP) implicated in type II diabetes. We find that in both monolayers and bila ...[more]