Ontology highlight
ABSTRACT:
SUBMITTER: Bruera G
PROVIDER: S-EPMC3838846 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bruera Gemma G Cannita Katia K Giordano Aldo Victor AV Vicentini Roberto R Ficorella Corrado C Ricevuto Enrico E
BioMed research international 20131106
Four-drug regimens, such as FIr-B/FOx schedule, can improve efficacy of first-line treatment of metastatic colorectal cancer (MCRC) patients. The present study specifically evaluates feasibility of FIr-B/FOx first-line intensive regimen in fit young-elderly MCRC patients, representing approximately 40% of overall MCRC patients. Activity, efficacy, and safety were equivalent to overall MCRC patients, not significantly different according to KRAS genotype. Clinical outcome was significantly prolon ...[more]